Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postsynaptic control of plasticity in developing somatosensory cortex

B L Schlaggar1, K Fox, D D O'Leary

  • 1Molecular Neurobiology Laboratory, Salk Institute, La Jolla, California 92037.

Nature
|August 12, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Language and sound exposure across neonatal intensive care hospitalization and relationships with early outcome.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Can We Miniaturize CT Technology for a Successful Mobile Stroke Unit Roll-Out?

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2023
Same author

Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts.

Communications biology·2023
Same author

Tool for automatic macrozone characterization from EBSD data sets of titanium alloys.

Journal of applied crystallography·2023
Same author

The Effects of a Perindopril-Based Regimen in Relation to Statin Use on the Outcomes of Patients with Vascular Disease: a Combined Analysis of the ADVANCE, EUROPA, and PROGRESS Trials.

Cardiovascular drugs and therapy·2022
Same author

The impact of 10-valent pneumococcal vaccine introduction on invasive disease in Fiji.

The Lancet regional health. Western Pacific·2022
Same journal

Incoming US science academy chief vows to 'double down' on research.

Nature·2026
Same journal

Author Correction: Synthesis of enantioenriched atropisomers by biocatalytic deracemization.

Nature·2026
Same journal

Electrodeposited self-assembled molecules for perovskite photovoltaics.

Nature·2026
Same journal

Neutrino's nursery found: the 'Shadow Blaster'.

Nature·2026
Same journal

Dementia risk in middle-aged people linked to a blood protein.

Nature·2026
Same journal

Daily briefing: What's really happening with trust in science.

Nature·2026
See all related articles

Postsynaptic activation is crucial for the brain

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Neuroplasticity

Background:

  • Synaptic rearrangement during development is thought to be driven by correlated neural activity.
  • The prevailing model suggests postsynaptic neurons detect synchronous afferent input, strengthening connections.
  • Evidence primarily comes from the visual system, showing correlated input is vital for ocular dominance column segregation.

Purpose of the Study:

  • To investigate if developmental plasticity in the rodent somatosensory cortex (S1) follows similar principles to the visual system.
  • To determine the role of postsynaptic activation in the critical period plasticity of S1 'barrels'.

Main Methods:

  • Selective disruption of postsynaptic activation in rat S1 using a glutamate receptor antagonist.

Related Experiment Videos

  • Manipulation of sensory periphery input during the critical developmental period.
  • Analysis of rearrangements in the somatotopic patterning of thalamocortical afferents.

    • Main Results:

    • Disruption of postsynaptic activation significantly inhibited plasticity in S1.
    • This inhibition occurred in response to sensory periphery manipulations during the critical period.
    • The findings demonstrate a key role for postsynaptic activity in S1 plasticity.

    Conclusions:

    • Postsynaptic activation plays a prominent role in critical period plasticity within the primary somatosensory cortex (S1).
    • The mechanisms governing plasticity in the somatosensory system may share similarities with those in the visual system.