Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine

S Araki1, T Tanigawa, S Ishizu

  • 1Department of Public Health, Faculty of Medicine, University of Tokyo, Japan.

Archives of Environmental Health
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear SIPA1 activates integrin β1 promoter and promotes invasion of breast cancer cells.

Oncogene·2014
Same author

[Graft replacement for surgical repair of coarctation of the aorta in adults].

Kyobu geka. The Japanese journal of thoracic surgery·2011
Same author

[Successful repair for impending ruptured subclavian artery aneurysm; report of a case].

Kyobu geka. The Japanese journal of thoracic surgery·2009
Same author

Field trial of time-spreading and wavelength-hopping OCDM transmission using FBG en/decoders.

Optics express·2009
Same author

Rapid alphabeta TCR-mediated responses in gammadelta T cells transduced with cancer-specific TCR genes.

Gene therapy·2009
Same author

Human gammadelta T cells modulate the mite allergen-specific T-helper type 2-skewed immunity.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2007
Same journal

Exposure of a Cree population living near mine tailings in northern Quebec (Canada) to metals and metalloids.

Archives of environmental health·2006
Same journal

Relationship between health status and psychological distress among the inhabitants in a methylmercury-polluted area in Japan.

Archives of environmental health·2006
Same journal

Medical assessment of the health effects of short leisure trips.

Archives of environmental health·2006
Same journal

Association between exposure to cadmium and blood pressure in Japanese peoples.

Archives of environmental health·2006
Same journal

Development and reduction of hypertension and oxidative stress among detergent industry workers.

Archives of environmental health·2006
Same journal

Evaluation of residential exposure to intermediate frequency magnetic fields.

Archives of environmental health·2006
See all related articles

Past exposure to aromatic amines like benzidine significantly reduced CD4+ T lymphocytes in dyestuff workers. Measuring CD4+ cell counts can serve as a biological marker for aromatic amine exposure.

Area of Science:

  • Immunology
  • Occupational Health
  • Toxicology

Background:

  • Benzidine and beta-naphthylamine are aromatic amines used in the chemical industry.
  • Occupational exposure to these chemicals may impact the human immune system.

Purpose of the Study:

  • To investigate the effects of past exposure to benzidine and beta-naphthylamine on T lymphocyte subpopulations in male dyestuff workers.
  • To determine if CD4+ T lymphocytes can serve as a biological marker for aromatic amine exposure.

Main Methods:

  • Analysis of T lymphocyte subpopulations (CD4+, CD8+, CD3+), CD16+ lymphocytes, and total lymphocytes in peripheral blood.
  • Comparison between high-exposure (aromatic amine production), low-exposure (dyestuff handling), and control (no exposure) groups.

Related Experiment Videos

Main Results:

  • High-exposure workers showed significantly lower total and relative numbers of CD4+ and CD3+ T lymphocytes compared to controls (p < .01).
  • Relative CD16+ lymphocyte counts were significantly higher in the high-exposure group (p < .05), but total counts did not differ.
  • No significant immune system differences were observed between the low-exposure group and controls.

Conclusions:

  • Occupational exposure to aromatic amines may lead to a decrease in circulating CD4+ T lymphocytes.
  • CD4+ lymphocyte counts are a potential biological marker for assessing past exposure to aromatic amines.