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Fibrin adhesive in radical mastectomy
P Udén1, K Aspegren, G Balldin
1Department of Surgery, Malmö Allmänna sjukhus, Lund University, Sweden.
Objective:
To find out if fibrin adhesive glue applied locally would reduce the incidence of seroma after modified radical mastectomy for breast cancer.
Design:
Prospective randomised study.
Setting:
City hospital, Sweden.
Subjects:
68 women undergoing modified radical mastectomy with axillary clearance for breast cancer.
Main Outcome Measures:
Amount of postoperative drainage, number of seromas aspirated volumes; length of hospital stay, influence of surgeon operating.
Results:
Seromas developed in a total of 40/68 patients (59%), 23/36 in the fibrin adhesive group (64%) and 17/32 in the control group (53%); p = 0.5 (95% confidence interval of the difference--0.13 to 0.34). There were no significant differences in the volume of aspirations or in hospital stay. The skill of the surgeon influenced the incidence of seromas, but the differences were not significant (p = 0.5).
Conclusion:
Local application of a fibrin adhesive glue has no effect on the incidence of seroma formation after modified radical mastectomy.