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Dopaminergic resistance in a case of invasive macroprolactinoma
D Schwarzstein1, A García-Patterson, G Giménez
1Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
Journal of Endocrinological Investigation
|June 1, 1993
Abstract:
Invasive prolactinoma is a relatively infrequent variety of macroprolactinoma characterized by a fast and aggressive growth, with infiltration to adjacent structures, and whose management is frequently difficult. We present the case of a fatal invasive macroprolactinoma in whom resistance to different dopaminergic drugs developed.
Insights
Invasive prolactinoma, a rare aggressive tumor, can be challenging to manage. This case highlights resistance to standard dopaminergic drugs, leading to a fatal outcome.
Area of Science:
- Endocrinology
- Oncology
- Neurosurgery
Background:
- Invasive prolactinoma is a rare subtype of macroprolactinoma.
- Characterized by rapid, aggressive growth and infiltration of adjacent structures.
- Management is often complex and challenging.
Observation:
- Presents a case of invasive prolactinoma.
- The patient developed resistance to multiple dopaminergic therapies.
- The invasive prolactinoma ultimately proved fatal.
Findings:
- Demonstrates a rare instance of invasive prolactinoma.
- Highlights the potential for treatment resistance to dopaminergic agents.
- Illustrates the aggressive nature and poor prognosis in some cases.
Implications:
- Suggests a need for alternative therapeutic strategies for resistant invasive prolactinomas.
- Underscores the importance of early diagnosis and aggressive management.
- Contributes to understanding the clinical course and challenges in managing this rare tumor.