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Platelet-activating factor inhibits excitatory transmission in rat neostriatum
Z G Jiang1, T L Yue, G Feuerstein
1Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201-3098.
Abstract:
Platelet-activating factor (PAF) and its receptor have been found in mammalian brain but its neuronal action is unclear. Using brain slice and whole-cell patch-clamp techniques, it was found that PAF dose-dependently inhibited excitatory postsynaptic current in neostriatal neurons but not the current induced by exogenously applied glutamate. These effects were also observed with the synthetic agonist 2-methylcarbamyl-PAF and were blocked by BN50739, a competitive antagonist at PAF receptors. It is concluded that PAF acts presynaptically to inhibit the release of glutamate at excitatory synapses in the neostriatum.