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New polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) not linked to schizophrenia in five
D G Sidenberg1, A S Bassett, L Demchyshyn
1Section of Neurogenetics, Laboratories of the Clarke Institute of Psychiatry, Toronto, Ont., Canada.
Human Heredity
|September 1, 1993
Abstract:
A new HincII polymorphism for the human serotonin 1D receptor variant (5-HT1D beta) is reported. In light of evidence indicating possible dysfunction of the 5-HT neurotransmitter system in schizophrenia, this new 5-HT receptor polymorphism was tested for linkage to schizophrenia in 5 Canadian pedigrees. Although 1 of the 5 pedigrees tested had a slightly positive lod score, there was no evidence overall for linkage to schizophrenia under dominant, recessive, or two locus models.