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AOA's current trends in pharmacology and therapeutics histamine and antihistamine agents
1Southern College of Optometry, Memphis, TN 38104.
Background:
Drugs that selectively block the H-1 subtype of histamine receptors are known as classical antihistamines.
Methods:
These agents are used for the symptomatic relief of allergies and colds and because they act in a manner similar to atropine, and are often used for their anticholinergic effects. They are readily available as prescription and over-the-counter medications and it is likely that the practicing optometrist will encounter these drugs in their patient population.
Results:
Antihistamines produces several common ocular side effects that include blurred vision, diplopia, mydriasis, and decreased lacrimation.
Conclusions:
This article reviews the physiology of histamine as it relates to the pharmacology of antihistamines, the mechanism of action, and adverse effects associated with the classical antihistamines.