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Stabilization of thymopentin and preservation of its pharmacological properties by 2-hydroxypropyl-beta-cyclodextrin
N D Brown1, D L Butler, P K Chiang
1Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
The Journal of Pharmacy and Pharmacology
|July 1, 1993
Abstract:
Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration.