Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoglobulin Gm allotypes in apes: comparison with man

J M Dugoujon1, A Blancher, S Hazout

  • 1CRPG, CNRS, CHU Purpan, Toulouse, France.

Journal of Medical Primatology
|January 1, 1993
PubMed
Summary

Immunoglobulin allotypes were analyzed in apes, revealing species-specific and shared phenotypes between humans and African apes. This research provides insights into primate immunoglobulin genetics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe.

Science advances·2019
Same author

A clinical and neurophysiological motor signature of Unverricht-Lundborg disease.

Revue neurologique·2017
Same author

Reference values for T, B and NK human lymphocyte subpopulations in adults.

Data in brief·2017
Same author

Influence of age, sex and HCMV-serostatus on blood lymphocyte subpopulations in healthy adults.

Cellular immunology·2017
Same author

Allelic and Epitopic Characterization of Intra-Kidney Allograft Anti-HLA Antibodies at Allograft Nephrectomy.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
Same author

Bone marrow tryptase as a possible diagnostic criterion for adult systemic mastocytosis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016

Area of Science:

  • Immunogenetics
  • Primate Serology
  • Molecular Anthropology

Background:

  • Immunoglobulin allotypes are genetically determined structural variations of antibodies.
  • Understanding these allotypes in non-human primates can shed light on human immune system evolution.
  • Previous studies have identified some shared allotypes between humans and apes, but comprehensive analysis is limited.

Purpose of the Study:

  • To characterize G1m, G2m, and G3m immunoglobulin allotypes in various ape species.
  • To identify species-specific and shared allotypes among humans and African apes.
  • To contribute to the understanding of immunoglobulin polymorphism in primates.

Main Methods:

  • Serum samples from 245 apes (including chimpanzees, bonobos, gorillas, and orangutans) were collected.

Related Experiment Videos

  • The classical method of hemagglutination inhibition was employed to test for specific G1m, G2m, and G3m allotypes.
  • Phenotypic frequencies of immunoglobulin allotypes were determined for each species.

    • Main Results:

    • Significant variation in immunoglobulin allotypes was observed across different ape species.
    • Certain G1m, G2m, and G3m allotypes exhibited species-specific patterns.
    • A few immunoglobulin allotypes were found to be shared between humans and African apes, notably chimpanzees and gorillas.
    • The distribution of G1m (1,2,3,17), G2m (23), and G3m (5,6,10,11,13,14,15,16,21,24,28) allotypes varied considerably.

    Conclusions:

    • The study confirms the presence of diverse immunoglobulin allotypes in apes, with distinct patterns in different species.
    • The identification of shared allotypes between humans and African apes supports a close evolutionary relationship and potential gene flow or common ancestry.
    • These findings enhance our knowledge of primate immunogenetics and provide a basis for further comparative studies of immune system evolution.