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Calcium mass transfer and kinetics in CAPD using calcium-free solutions
F Malberti1, B Corradi, E Imbasciati
1Servizio Dialisi, Ospedale Maggiore, Lodi, Italy.
Summary
Patients on peritoneal dialysis can gain or lose calcium depending on the dialysate solution used. Higher calcium concentrations in the dialysis fluid lead to calcium gain, while lower concentrations result in calcium loss.
Area of Science:
- Nephrology
- Biomedical Engineering
- Clinical Chemistry
Background:
- Continuous ambulatory peritoneal dialysis (CAPD) is a treatment for kidney failure.
- Calcium balance is crucial for patients undergoing dialysis.
- Understanding calcium transport during peritoneal dialysis is essential for optimizing treatment.
Purpose of the Study:
- To evaluate peritoneal calcium mass transfer (CaMT) in CAPD patients.
- To assess changes in serum and dialysate ionized calcium (iCa) levels.
- To analyze the dialysate-to-plasma (D/P) ratio for calcium with varying calcium concentrations in peritoneal solutions.
Main Methods:
- 12 CAPD patients participated in the study.
- Six-hour dwell exchanges were performed using peritoneal solutions with zero, 1.25 mmol/L, and 1.75 mmol/L calcium.
- Peritoneal calcium mass transfer, serum iCa, effluent dialysate iCa, and D/P ratios were measured.
Main Results:
- Patients gained calcium with standard (1.75 Ca) solutions (+0.41 +/- 0.6 mmol/L).
- Calcium was lost with 1.25 Ca (-0.67 +/- 0.4 mmol/L) and zero Ca (-2.4 +/- 0.4 mmol/L) solutions.
- The D/P ratio for iCa reached equilibrium at approximately 0.84, indicating a balance between dialysate and serum iCa.
Conclusions:
- Dialysate and serum ionized calcium reach equilibrium at a D/P ratio of about 0.84.
- Using 1.75 mmol/L calcium solutions results in net calcium gain for CAPD patients.
- 1.25 mmol/L calcium solutions lead to calcium loss through diffusion and ultrafiltration.