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Taxoid side-chain structure determination by electrospray ionization tandem mass spectrometry
F Bitsch1, C H Shackleton, W Ma
1Children's Hospital Oakland Research Institute, CA 94609.
Rapid Communications in Mass Spectrometry : RCM
|October 1, 1993
Abstract:
A method to elucidate the side-chain structure of novel taxoids was developed through use of electrospray ionization tandem mass spectrometry. The intact side-chain fragments produced by source fragmentation in the atmosphere-to-vacuum interface were further dissociated in the collision cell of a triple quadrupole mass spectrometer. The distinctive collisionally induced dissociation mass spectra were remarkably informative and gave detailed information on the side-chain functionalities. This technique proved valuable in the characterization of new taxoids produced by yew-tree cell cultures.