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Thyroid hormone stimulates phosphoglycerate mutase activity and isozyme transition in rat muscle tissues
M Esteller1, J Ureña, J Carreras
1Unitat de Bioquímica, Facultat de Medicina, Universitat de Barcelona, Spain.
Life Sciences
|January 1, 1994
Abstract:
Triiodothyronine (T3) increases phosphoglycerate mutase (PGAM) specific activity in rat skeletal and cardiac muscles. This increase is concomitant with an increase in the proportion of phosphoglycerate mutase isozymes which contain type-M subunit. Propylthiouracil (PTU), an anti-hormone, not only decreases phosphoglycerate mutase activity with respect to control rats, but also decreases the total M subunit contents. In liver, which only possesses type-B subunit phosphoglycerate mutase, none of the effects were detected.