Related Experiment Videos
[A comparison of two delivery devices on the bronchodilatory effects of procaterol from a metered dose inhaler]
M Kishida1, H Uchiyama, H Matsumoto
1Second Department of Pediatrics, Toho University School of Medicine.
Insights
This study found no significant difference in bronchodilatory effects between a Volumatic spacer and a corniced extension tube for asthma inhalers in children. Both devices effectively deliver procaterol during acute asthma attacks.
Area of Science:
- Pediatric Pulmonology
- Respiratory Medicine
- Pharmacology
Background:
- Metered dose inhalers (MDIs) are crucial for asthma management.
- Spacer devices and extension tubes improve MDI drug delivery.
- Acute asthma attacks in children require effective bronchodilator delivery.
Purpose of the Study:
- To compare the bronchodilatory efficacy of a Volumatic spacer versus a corniced extension tube for procaterol delivery.
- To evaluate the impact of these devices on key respiratory function parameters in pediatric asthma patients.
Main Methods:
- A double-blind study involving 18 children with acute asthma attacks.
- Procaterol was administered via MDI with either a Volumatic spacer or a corniced extension tube.
- Measurements included Forced Expiratory Volume in 1 second (FEV1), Forced Vital Capacity (FVC), Maximal Flow Rate at 50% and 25% of vital capacity (V50, V25), and Peak Expiratory Flow Rate (PEFR).
Main Results:
- Mean percent increase in FEV1 was 55.6% with Volumatic and 46.2% with the extension tube.
- No statistically significant differences were observed in FEV1, FVC, V50, V25, or PEFR between the two devices.
- Both devices demonstrated comparable bronchodilatory effects.
Conclusions:
- The Volumatic spacer and the corniced extension tube provide similar bronchodilatory responses in children with acute asthma.
- The corniced extension tube offers advantages of lower cost and greater portability.
- Both devices are effective for delivering procaterol in acute pediatric asthma exacerbations.
Abstract:
The bronchodilatory response to procaterol delivery by a metered dose inhaler with a spacer device (Volumatic) and a corniced extension tube was studied in a double blind manner in 18 asthmatic children, who were brought to our emergency room with acute attacks. The mean percent increase in forced expiratory volume in 1 second (FEV1) with the Volumatic was 55.6 +/- 39.3%, and 46.2 +/- 37.4% with the extension tube. There were no significant differences in the mean percent increase in FEV1, forced vital capacity (FVC), maximal flow rate at 50% of vital capacity (V50), maximal flow rate at 25% of vital capacity (V25) and peak expiratory flow rate (PEFR) between the two devices. It is concluded that there is no difference in the bronchodilatory effects of the two devices. The corniced extension tube has the advantage of being less expensive and more convenient to carry around.