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Endogenous hepoxilin A3, produced under short duration of high shear-stress, inhibits thrombin-induced aggregation in
1Department of Life Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Biochimica Et Biophysica Acta
|February 23, 1994
Abstract:
The effect of short duration of shear-stress (350 dyne/cm2, 20 ms) on platelet-aggregation has been assessed. This treatment inhibits thrombin-induced but not ADP- or collagen-induced aggregation. The inhibitory effect is mediated by endogenous hepoxilin A3. This conclusion is based on the following observations: (a) The shear-stress effect is abolished by lipoxygenase inhibitors. (b) Hepoxilin A3 mimics the shear-stress effect.