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Mood variability in normal subjects on lithium

C D Barton¹, D Dufer, R Monderer

¹Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

Biological Psychiatry

|December 15, 1993

Summary

This study found that lithium carbonate did not significantly alter mood or mood variability in healthy volunteers over five weeks. Modest lithium doses showed no substantial mood-stabilizing effects in this normal subject group.

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Area of Science:

Psychopharmacology
Neuroscience
Clinical Psychology

Background:

Lithium carbonate is a common mood stabilizer.
Its effects on mood regulation in healthy individuals require further investigation.

Purpose of the Study:

To assess the mood-stabilizing effects of lithium carbonate in normal volunteers.
To evaluate changes in mood, anxiety, and energy levels.

Main Methods:

A randomized, placebo-controlled crossover study.
30 healthy subjects received lithium carbonate or placebo for 5 weeks.
Mood was assessed daily using visual analogue scales (VAMS) and weekly using segmented visual analogue scales (SVAS) and Profile of Mood States (POMS).

Main Results:

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No significant differences in mean mood or mood variability were observed between lithium and placebo conditions.
Mood ratings from VAMS and SVAS showed high correlation but no condition-specific differences.
Self-rated mood variability decreased over time in both conditions.

Conclusions:

Lithium carbonate, at a mean serum level of 0.54 mEq/L, did not demonstrate a substantial mood-stabilizing effect in healthy subjects over a 5-week period.
Further research may be needed to explore lithium's effects in different populations or at varying dosages.