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Mood variability in normal subjects on lithium

C D Barton1, D Dufer, R Monderer

  • 1Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD.

Biological Psychiatry
|December 15, 1993
PubMed
Summary
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This study found that lithium carbonate did not significantly alter mood or mood variability in healthy volunteers over five weeks. Modest lithium doses showed no substantial mood-stabilizing effects in this normal subject group.

Area of Science:

  • Psychopharmacology
  • Neuroscience
  • Clinical Psychology

Background:

  • Lithium carbonate is a common mood stabilizer.
  • Its effects on mood regulation in healthy individuals require further investigation.

Purpose of the Study:

  • To assess the mood-stabilizing effects of lithium carbonate in normal volunteers.
  • To evaluate changes in mood, anxiety, and energy levels.

Main Methods:

  • A randomized, placebo-controlled crossover study.
  • 30 healthy subjects received lithium carbonate or placebo for 5 weeks.
  • Mood was assessed daily using visual analogue scales (VAMS) and weekly using segmented visual analogue scales (SVAS) and Profile of Mood States (POMS).

Main Results:

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  • No significant differences in mean mood or mood variability were observed between lithium and placebo conditions.
  • Mood ratings from VAMS and SVAS showed high correlation but no condition-specific differences.
  • Self-rated mood variability decreased over time in both conditions.

Conclusions:

  • Lithium carbonate, at a mean serum level of 0.54 mEq/L, did not demonstrate a substantial mood-stabilizing effect in healthy subjects over a 5-week period.
  • Further research may be needed to explore lithium's effects in different populations or at varying dosages.