[Effects of scorpion injection on interleukin 1 and pathology in experimental glomerulonephritis in situ]

The model of experimental glomerulonephritis in situ in rats was established by administration of C-BSA. 24 male Wistar rats were randomly assigned to three groups: C-BSA, control and C-BSA+scorpion (scorpion injection, ip, 1.0 g/kg, once/day). At the end of 4th week, the bioactivity of serum IL-1 was assayed by thymocyte proliferation method and the renal pathology was checked up. Urine sample was collected for 24 hour once/week for protein determination.

Quantity of proteinuria in scorpion group was reduced significantly in comparing with C-BSA group. Level of IL-1 was significantly lower in scorpion group than that in C-BSA group. Injury of renal tissue also was mild in the treated group. These results suggested that scorpion injection could suppress the activities of IL-1 and ameliorate the pathological injury in this experimental glomerulonephritis in situ.