[Prenatal toxicology studies using sevin (carbaryl) in Wistar rats]

Oral administration of three doses of Carbaryl at 200 or 350 mg/kg body weight to pregnant female rats at various stages of fetal development had only slight teratogenic activity. Three doses of Carbaryl at 350 mg/kg given during the late embryonic or early fetal stages of pregnancy delayed fetal development; in the pre-embryonic stage it produced increased mortality of fertilized ova and increased the degree of retardation of individual fetuses. Similar results were produced by six doses at 200 mg/kg given on alternate days between the 5th and 15th days of embryonic development. It was concluded that the effects of Carbaryl on intrauterine development in rats were related to dosage.