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[Prenatal toxicology studies using sevin (carbaryl) in Wistar rats]
Oral administration of three doses of Carbaryl at 200 or 350 mg/kg body weight to pregnant female rats at various stages of fetal development had only slight teratogenic activity. Three doses of Carbaryl at 350 mg/kg given during the late embryonic or early fetal stages of pregnancy delayed fetal development; in the pre-embryonic stage it produced increased mortality of fertilized ova and increased the degree of retardation of individual fetuses. Similar results were produced by six doses at 200 mg/kg given on alternate days between the 5th and 15th days of embryonic development. It was concluded that the effects of Carbaryl on intrauterine development in rats were related to dosage.
Oral administration of three doses of Carbaryl at 200 or 350 mg/kg body weight to pregnant female rats at various stages of fetal development had only slight teratogenic activity. Three doses of Carbaryl at 350 mg/kg given during the late embryonic or early fetal stages of pregnancy delayed fetal development; in the pre-embryonic stage it produced increased mortality of fertilized ova and increased the degree of retardation of individual fetuses. Similar results were produced by six doses at 200 mg/kg given on alternate days between the 5th and 15th days of embryonic development. It was concluded that the effects of Carbaryl on intrauterine development in rats were related to dosage.