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Delayed hypersensitivity drug reactions diagnosed by patch testing

J M Calkin1, H I Maibach

  • 1Dermatology Department, University of California Medical School, San Francisco 94143-0989.

Contact Dermatitis
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

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Diagnosing delayed drug hypersensitivity reactions can be time-consuming. This review explores using patch testing as a diagnostic aid for drug eruptions, offering a definition for wider acceptance.

Area of Science:

  • Dermatology
  • Clinical Immunology
  • Pharmacology

Background:

  • Drug reactions are frequent in both inpatient and outpatient settings.
  • Current diagnostic methods like oral or parenteral drug challenges are effective but lengthy.
  • Delayed hypersensitivity drug eruptions pose a diagnostic challenge.

Purpose of the Study:

  • To review the efficacy of patch testing in diagnosing delayed hypersensitivity drug eruptions.
  • To analyze existing control data for patch testing in drug hypersensitivity.
  • To propose an operational definition for diagnostic patch testing in this context.

Main Methods:

  • Systematic review of studies investigating patch testing for drug eruptions.
  • Analysis of control data to assess the reliability of patch testing.

Related Experiment Videos

  • Development of an operational definition for diagnostic patch testing.

    • Main Results:

    • Patch testing shows potential as a diagnostic tool for delayed hypersensitivity drug eruptions.
    • Review of control data is crucial for validating patch test results.
    • An operational definition may enhance the acceptance and standardization of patch testing.

    Conclusions:

    • Diagnostic patch testing is a viable alternative to time-consuming drug challenges for certain drug eruptions.
    • Standardized criteria and further research are needed to fully establish patch testing's role.
    • Wider acceptance of patch testing can improve the diagnosis of delayed drug hypersensitivity.