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In vitro evidence of delayed-type hypersensitivity to hydrocortisone
S M Wilkinson1, J S English, D L Mattey
1Department of Dermatology, Staffordshire Hospital Centre, Stoke-on-Trent, UK.
Contact Dermatitis
|November 1, 1993
Abstract:
Hypersensitivity to topical hydrocortisone is becoming increasingly recognized. We present further evidence that this is mediated via a delayed-type hypersensitivity reaction. A hydrocortisone: albumin complex was able to induce a proliferative response in the peripheral blood mononuclear cells of patients allergic to hydrocortisone. Protein binding of hydrocortisone or a degradation product may be important in the development of corticosteroid allergy.