[Expression of mutant P53 gene protein product in human bladder carcinoma]

Expression of P53 protein was detected immunohistochemically in formalin-fixed, paraffin-embedded tissues from 67 patients with bladder carcinoma and 6 normal bladder controls. P53 protein was found positively in 34 of the 67 tumors, whereas no normal bladder controls and no non-cancer tissue cells on tumor sections was stained positively for P53 protein. The percentage of staining for P53 was higher in poorly-differentiated and in invasive tumors than in well and moderately differentiated and in superficial tumors. We also found that P53 positive staining was closely related to tumors recurrence. Hence, the expression of P53 may be used as a tumor marker predicting the histograde, clinical stage and recurrence.