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Related Experiment Videos

The dark choroid in systemic argyrosis

S Y Cohen1, G Quentel, D Egasse

  • 1Department of Ophthalmology, University of Paris XII-Creteil, France.

Retina (Philadelphia, Pa.)
|January 1, 1993
PubMed
Summary
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Systemic argyrosis, a silver-induced skin discoloration, can affect the retina. Fluorescein angiography revealed a characteristic

Area of Science:

  • Ophthalmology
  • Toxicology
  • Medical Imaging

Background:

  • Argyrosis is a known condition causing skin discoloration due to silver exposure.
  • Ocular manifestations like conjunctival and corneal discoloration have been documented.
  • Retinal involvement and specific fluorescein angiography patterns in argyrosis were previously unreported.

Observation:

  • Six patients with iatrogenic systemic argyrosis underwent fluorescein angiography.
  • A consistent finding of a 'dark choroid' was observed in all patients.
  • Red light and infrared imaging revealed a distinct 'leopard spot' pattern on the fundus.

Findings:

  • Silver deposits in Bruch's membrane are hypothesized to cause choroidal fluorescence obscuration.
  • The 'leopard spot' pattern may represent visualization of choriocapillary units with long-wavelength light.

Related Experiment Videos

  • These angiographic findings represent the first reported retinal changes in systemic argyrosis.

    • Implications:

    • Systemic argyrosis can lead to characteristic retinal and choroidal changes detectable by fluorescein angiography.
    • The 'dark choroid' finding is not exclusive to retinal dystrophies and can be seen in argyrosis.
    • This study expands the understanding of ocular manifestations of heavy metal toxicity.