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Conductometric determination of some pharmaceutically important thiol compounds in dosage forms
1Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Egypt.
Acta Pharmaceutica Hungarica
|November 1, 1993
Summary
A new conductometric method accurately determines five thiol compounds, including N-acetylcysteine and captopril, in pharmaceuticals. This simple, precise technique offers reliable analysis for bulk and dosage forms.
Area of Science:
- Analytical Chemistry
- Pharmaceutical Analysis
Background:
- Accurate quantification of thiol compounds is crucial in pharmaceutical quality control.
- Existing methods may require complex procedures or specialized equipment.
Purpose of the Study:
- To develop a direct, simple, and accurate semimicro conductometric method for determining five key thiol compounds.
- To validate the method for both bulk pharmaceutical ingredients and finished dosage forms.
Main Methods:
- Utilized a direct semimicro conductometric titration in an aqueous medium.
- Employed lead nitrate as the titrant.
- Detected the titration endpoint using conductometry.
Main Results:
- Successfully determined N-acetylcysteine, captopril, D-penicillamine, 6-mercaptopurine, and thioguanine.
- Achieved results comparable to official methods, demonstrating accuracy and precision.
- Validated the method's applicability to both bulk and dosage forms.
Conclusions:
- The proposed conductometric method is a viable, accurate, and precise technique for analyzing important thiol-containing pharmaceuticals.
- This method offers a simple alternative for routine quality control in the pharmaceutical industry.