Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ferric reductases or flavin reductases?

M Fontecave1, J Covès, J L Pierre

  • 1Laboratoire d'Etudes Dynamiques et Structurales de la Sélectivité, Unité de Recherche Associée au CNRS 332, Université Joseph Fourier, Grenoble, France.

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
|January 1, 1994
PubMed
Summary

Microorganisms need ferric reductases to absorb iron from siderophores. These enzymes share properties with flavin reductases, suggesting iron reduction relies on reduced flavins.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SEOM clinical guidelines for the treatment of malignant pleural mesothelioma (2020).

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2021
Same author

Structural and functional studies of the metalloregulator Fur identify a promoter-binding mechanism and its role in <i>Francisella tularensis</i> virulence.

Communications biology·2018
Same author

Spectroscopic investigations of a semi-synthetic [FeFe] hydrogenase with propane di-selenol as bridging ligand in the binuclear subsite: comparison to the wild type and propane di-thiol variants.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry·2018
Same author

A noble metal-free proton-exchange membrane fuel cell based on bio-inspired molecular catalysts.

Chemical science·2017
Same author

Ruthenium-cobalt dinuclear complexes as photocatalysts for CO<sub>2</sub> reduction.

Chemical communications (Cambridge, England)·2017
Same author

SEOM clinical guidelines for the treatment of non-small cell lung cancer (NSCLC) 2015.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2015

Area of Science:

  • Biochemistry
  • Microbiology
  • Enzymology

Background:

  • Iron assimilation is crucial for microbial life.
  • Ferrisiderophores are key iron chelators used by microorganisms.
  • Ferric reductases are enzymes involved in iron mobilization.

Purpose of the Study:

  • To describe the structural and catalytic properties of ferric reductases.
  • To compare ferric reductases with other known reductases.
  • To elucidate the role of flavins in microbial iron assimilation.

Main Methods:

  • Enzyme characterization.
  • Structural analysis of ferric reductases.
  • Comparative enzymatic studies.

Main Results:

Related Experiment Videos

  • Ferric reductases share common structural and catalytic properties.
  • These properties are identical to those of flavin reductases.
  • Evidence suggests a direct link between flavin reductases and iron reduction.

Conclusions:

  • Microbial iron assimilation heavily relies on ferric reductases.
  • Flavin reductases are likely the primary source of reduced flavins for iron reduction.
  • This finding provides a unified mechanism for iron reduction in microorganisms.