Factors affecting the validity of the standard blood pressure cuff

Fifty-eight patients, 31 women and 27 men, with a wide range of upper arm circumferences (20-43 cm), ages (16-82 years) and body mass indices (16-55 kg m-2) were studied. The direct blood pressure was measured in the brachial artery in one arm and simultaneously the indirect pressure was measured in the other arm using a large standard cuff (rubber bag 12 x 35 cm). The mean intra-arterial blood pressure was (systolic/diastolic) 137 +/- 25 mmHg (SD)/76 +/- 10 mmHg. With the cuff the mean blood pressure was 134 +/- 23 mmHg/85 +/- 11 mmHg. The cuff significantly underestimated the systolic blood pressure (3.2 +/- 11.4 mmHg, range -25-30 mmHg) while the diastolic pressure was overestimated significantly (8.8 +/- 8.5 mmHg, range -32-14 mmHg). The direct/indirect blood pressure difference correlated significantly to the intra-arterial systolic and diastolic pressures (systolic/diastolic; r = 0.44, P = 0.0006/r = 0.36, P = 0.0062), but only to the auscultatory diastolic pressure (r = -0.02, P = 0.9/r = -0.45, P = 0.0004). The direct/indirect difference correlated significantly to the arm circumference (r = -0.33, P = 0.01/r = -0.30, P = 0.02) as did the diastolic direct/indirect difference to pulse rate (r = 0.34, P = 0.009). Age did not correlate significantly to the direct/indirect blood pressure difference in this study (r = -0.02, P = 0.9/r = -0.10, P = 0.5). It can be concluded that in addition to the ratio between the arm circumference and the width of the cuff (rubber bag), there are other sources of systematic errors of indirect blood pressure measurement, in particular pulse rate and the level of indirect blood pressure. If corrections could be made with regard to these variables, it is obvious that the reliability of the indirect method, especially when used in epidemiological contexts, would increase.