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Related Experiment Videos

Negative-type electroretinogram from cisplatin toxicity

M F Marmor1

  • 1Department of Ophthalmology, Stanford University School of Medicine, California.

Documenta Ophthalmologica. Advances in Ophthalmology
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

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Cisplatin overdosage in ovarian cancer patients can cause persistent vision problems, including a specific color vision defect. This case highlights potential retinal on-pathway injury and suggests expanding diagnostic criteria for electroretinogram abnormalities.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Oncology

Background:

  • Cisplatin is a widely used platinum-based chemotherapy agent for various cancers, including ovarian cancer.
  • Ocular toxicity is a known, though less common, side effect of cisplatin therapy.
  • Understanding the specific mechanisms of cisplatin-induced visual impairment is crucial for patient management.

Observation:

  • A 68-year-old woman with ovarian cancer experienced visual acuity and color perception loss after cisplatin overdosage.
  • While visual acuity recovered, a persistent tritan color defect was noted over a year later.
  • Electroretinogram (ERG) showed stable abnormalities, including a negative-type scotopic response and reduced cone function.

Findings:

  • Cisplatin administration selectively impaired photopic on-responses in the retina.

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  • Scotopic oscillatory potentials were also reduced, suggesting broader retinal dysfunction.
  • The persistent tritan defect indicates long-term consequences on color vision pathways.

    • Implications:

    • Cisplatin may selectively damage retinal on-pathways, contributing to visual disturbances.
    • This case expands the differential diagnosis for negative-type electroretinograms.
    • Ophthalmologists should consider cisplatin toxicity in patients presenting with unexplained visual deficits and ERG abnormalities.