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Related Experiment Videos

Miliary tuberculosis in pregnancy

C E Henderson1, R Turk, J Dobkin

  • 1Department of Obstetrics and Gynecology, Jack D. Weiler Hospital, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

Journal of the National Medical Association
|September 1, 1993
PubMed
Summary
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Diagnosing miliary tuberculosis in pregnancy is challenging, especially without typical risk factors. Placental examination offers a rapid method for early diagnosis of this uncommon condition.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pathology

Background:

  • Miliary tuberculosis (TB) during pregnancy is rare and difficult to diagnose.
  • It is often linked to risk factors like HIV, substance abuse, or malignancy.
  • This study presents two cases of antepartum miliary TB in women without these risk factors.

Observation:

  • Patients presented with symptoms suggestive of miliary TB.
  • Initial diagnostic tests, including HIV screening and acid-fast bacilli stains of bronchial washings and ascitic fluid, were negative.
  • Cultures from ascitic fluid and bronchial biopsies took several weeks to yield positive results for Mycobacterium.

Findings:

  • Acid-fast bacilli were rapidly identified (within 24 hours) in placental tissue sections from both patients.

Related Experiment Videos

  • Placental biopsy proved to be a significantly faster diagnostic tool compared to other methods.
  • This highlights the placenta as a key diagnostic site for extrapulmonary TB in pregnancy.

    • Implications:

    • Early diagnosis of miliary tuberculosis in pregnancy can be facilitated by placental examination.
    • A high index of suspicion is crucial for diagnosing miliary TB during pregnancy.
    • Pathologic examination of placental tissue may improve diagnostic timelines for challenging extrapulmonary TB cases in pregnant individuals.