Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Model experiments on measuring flow in microvessels using tracers

W J Federspiel1, K Malai

  • 1Department of Biomedical Engineering, Boston University, Massachusetts 02215.

Microvascular Research
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acidic sweep gas with carbonic anhydrase coated hollow fiber membranes synergistically accelerates CO2 removal from blood.

Acta biomaterialia·2015
Same author

Kinetics of CO2 exchange with carbonic anhydrase immobilized on fiber membranes in artificial lungs.

Journal of materials science. Materials in medicine·2015
Same author

Carbonic anhydrase immobilized on hollow fiber membranes using glutaraldehyde activated chitosan for artificial lung applications.

Journal of materials science. Materials in medicine·2013
Same author

A mathematical model to predict CO2 removal in hollow fiber membrane oxygenators.

Annals of biomedical engineering·2008
Same author

Acute in vivo testing of an intravascular respiratory support catheter.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2001
Same author

Specific removal of anti-A and anti-B antibodies by using modified dialysis filters.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2000
Same journal

Association between retinal microcirculation and cardiac function: A cross-sectional study using OCTA.

Microvascular research·2026
Same journal

Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.

Microvascular research·2026
Same journal

Association of circulating biomarkers of glycocalyx injury, sirtuin 1, and NFκB p65 in individuals with type 2 diabetes and concurrent arterial hypertension.

Microvascular research·2026
Same journal

Targeting miR-10 alleviates atherosclerosis by enhancing intestinal ABCA1-mediated cholesterol efflux and repairing intestinal barrier.

Microvascular research·2026
Same journal

The effect of acute high-intensity interval exercise on microvascular function and local skeletal muscle oxygenation.

Microvascular research·2026
Same journal

RNF213 deficiency in human iPSC-derived vascular organoids captures key feature of moyamoya disease vasculopathy.

Microvascular research·2026
See all related articles

Measuring microvessel flow velocity using tracer transit time can be inaccurate. This study experimentally confirms that tracer velocity measurements often differ from actual fluid velocity, especially in microvessel networks.

Area of Science:

  • Physiology
  • Biophysics
  • Fluid Dynamics

Background:

  • Microvessel flow velocity is crucial for understanding physiological processes.
  • Current tracer techniques measure transit time between two sites.
  • These methods often use area-weighted, not flow-weighted, sampling, leading to potential inaccuracies.

Purpose of the Study:

  • To experimentally validate theoretical predictions of velocity measurement error (VME) in microvessels.
  • To investigate the behavior of VME under physiological flow rates in physical models.
  • To assess the impact of microvessel networks on tracer velocity measurements.

Main Methods:

  • Used a physical model with single glass microvessels and networks.
  • Perfused with distilled water at physiological flow rates.

Related Experiment Videos

  • Measured mean tracer velocity (Vd) using injected Evans blue dye and actual mean flow velocity (Va) from effluent rates.

    • Main Results:

    • Experimental results confirmed significant VME, consistent with theoretical analysis.
    • Tracer velocity (Vd) was lower than actual velocity (Va) near the vessel entrance.
    • Vd approached Va past the entrance, but new VME emerged in downstream daughter vessels.

    Conclusions:

    • Tracer mean flow velocity measurements can significantly differ from actual fluid velocity in microvascular networks.
    • The observed VME behavior validates previous theoretical work.
    • Careful consideration of VME is necessary when interpreting tracer-based flow velocity data in microcirculation research.