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[Liver cell necrosis during administration of clozapine]
J E Hovens1, L M Vogtländer, H A Verhoeve
1Psychiatrisch Ziekenhuis H.C. Rümke groep, locatie Zeist.
Nederlands Tijdschrift Voor Geneeskunde
|February 12, 1994
Abstract:
A 38-year-old woman was treated for mutism with clozapine. After a week liver function disturbances developed, which disappeared when the treatment was discontinued. Histopathological investigation of a liver biopsy specimen revealed extensive liver cell necrosis. So far two patients have been described with cholestatic jaundice induced by clozapine, and one patient with toxic hepatitis due to clozapine.