Related Experiment Video
Updated: Aug 10, 2026

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
Published on: June 25, 2010
[Change in tryptamine metabolism in vitamin B12 deficiency]
Abstract:
The metabolism of tryptamine was studied in rats in health and in vitamin B12 deficiency. Excretion of cobalamin with urine before and after loading with tryptamine was studied. Daily excretion of tryptamine with urine in vitamin B12-deficient animals was normal or slightly increased. At the same time, the increase in tryptamine excretion with urine in response to tryptophan administration was 2-fold lower in vitamin B12-deficient rats as compared with controls. These data may be interpreted to occur due to a decrease in the rate of tryptamine metabolism in vitamin B12 deficiency in rats. Impairments in metabolism of biogenic amines appear to be involved in the development of neuro-mental diseases accompanied by vitamin B12 deficiency.
More Related Videos
10:38Simultaneous Quantification of Selected Kynurenines Analyzed by Liquid Chromatography-Mass Spectrometry in Medium Collected from Cancer Cell Cultures
Published on: May 9, 2020
12:07Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET
Published on: October 9, 2021
Related Concept Videos
Drugs Affecting Neurotransmitter Release or Uptake
Drugs Affecting Neurotransmitter Synthesis
Vitamins
Drug Toxicity: Dose-Dependent Reactions
Sulfur Assimilation
Amino Acid Biosynthetic Pathways