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Mucin-associated sialosyl-Tn antigen expression in gastric cancer correlates with an adverse outcome
J L Werther1, S Rivera-MacMurray, H Bruckner
1Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
British Journal of Cancer
|March 1, 1994
Abstract:
The expression of sialosyl-Tn (STn) antigen was evaluated by immunohistochemistry in primary gastric cancers. Twenty-one of 31 (68%) gastric cancers expressed STn, regardless of tumour location, stage or histological type. Eighty-one per cent of patients with STn-positive tumours died of their disease or had recurrent cancer, compared with 20% of patients with STn-negative tumours (P < 0.002). STn may be a useful prognostic marker in patients with gastric cancer.