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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay

Published on: March 2, 2011

[The adrenergic regulation of interleukin production by bone marrow cells during immobilization stress]

I A Khlusov, A M Dygaĭ, E D Gol'dberg

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |December 1, 1993
    PubMed

    Adrenergic regulation of interleukin-1 (IL-1) and interleukin-3 (IL-3) activities production by adhesive and nonadhesive bone marrow cells under immobilization stress has been studied in experiments on F1 (CBA x C57Bl/6) mice. 10-hour immobilization had been established to lead to rise of IL-1 and IL-3 activities in supernatants on days 2, 5 and 1, 2, 4, 5, 7 after stress, respectively. The use of Wilcoxon rank T-test demonstrated that alpha-adrenergic antagonist (dihydroergotaminum, 3.9 mg/kg) injection to stressed mice suppressed exclusively IL-1 activities production. At the same time, beta-adrenoblocker (propranolol, 5 mg/kg) inhibited IL-3 production. Thus, adrenergic structures take an active part in regulation of IL-1 and IL-3 production by haemopoiesis inducing microenvironment bone marrow cells under immobilization stress.

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