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Thyroid involvement in chronic inflammatory rheumatological disorders

G Bianchi1, G Marchesini, M Zoli

  • 1Instituto di Clinica Medica Generale e Terapia, Università di Bologna.

Clinical Rheumatology
|December 1, 1993
PubMed
Summary
This summary is machine-generated.

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Thyroid issues are common in rheumatological diseases like rheumatoid arthritis and psoriatic arthritis, showing increased thyroid volume and antibodies. This thyroid involvement occurs even in non-autoimmune related rheumatic conditions.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Immunology

Background:

  • The link between rheumatological and thyroid disorders, particularly rheumatoid arthritis and autoimmune thyroiditis, is well-established.
  • Limited research exists on thyroid involvement in other rheumatological conditions like psoriatic arthritis and ankylosing spondylitis.

Purpose of the Study:

  • To investigate thyroid volume, function, and antibody prevalence in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
  • To compare thyroid parameters in these patient groups with healthy controls.

Main Methods:

  • Ultrasound measurement of thyroid volume.
  • Assessment of thyroid function (fT4 levels).
  • Screening for anti-microsome and anti-thyroglobulin antibodies.

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Main Results:

  • Increased average thyroid volume and a 2-3 fold higher prevalence of thyroid enlargement in all rheumatological patient groups compared to controls.
  • Elevated fT4 levels and increased anti-microsome antibody prevalence in rheumatoid arthritis and psoriatic arthritis patients.
  • Thyroid alterations in rheumatoid arthritis were independent of disease activity, while in psoriatic arthritis, they were linked to active disease.

Conclusions:

  • Significant thyroid involvement is present in rheumatological disorders.
  • Thyroid dysfunction and enlargement are not exclusive to autoimmune rheumatic diseases.