Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement system and host defense against staphylococcal endophthalmitis

M J Giese1, B J Mondino, B J Glasgow

  • 1Jules Stein Eye Institute, University of California at Los Angeles 90024-1771.

Investigative Ophthalmology & Visual Science
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CLEFT LIP, ALVEOLUS AND PALATE IN AFRICAN NATIVES: AN UPDATE ON DEMOGRAPHICS AND MANAGEMENT OUTCOME.

African journal of medicine and medical sciences·2015
Same author

A Report on a Study of the Rural and Village School Children of Buncombe County, North Carolina for Tuberculosis.

Transactions of the American Clinical and Climatological Association·2011
Same author

An interesting case of recurrent temporomandibular joint dislocation.

The New Zealand dental journal·2009
Same author

Effects of Cy to sine Arabino side-Impregnated Bioerodible Polymers on Glaucoma Filtration Surgery in Rabbits.

Journal of glaucoma·2009
Same author

Partial resolution of acute ascending motor polyneuropathy after enucleation of an eye with metastatic melanoma.

The British journal of ophthalmology·2004
Same author

North Carolina macular dystrophy: clinicopathologic correlation.

Transactions of the American Ophthalmological Society·2002
Same journal

New Guidelines for Ophthalmic Genetic Studies.

Investigative ophthalmology & visual science·2026
Same journal

Genomic Copy Number Variants Associated With Strabismus and Amblyopia in the All of Us Research Program.

Investigative ophthalmology & visual science·2026
Same journal

Xanthophyll Carotenoid Intake, Plasma Levels, and Retinal Visualization in Aging and Age-Related Macular Degeneration: ALSTAR2.

Investigative ophthalmology & visual science·2026
Same journal

Enhanced Endocytosis and Mitochondrial Stress Underlie Severe Retinitis Pigmentosa With RHO P347L Mutant.

Investigative ophthalmology & visual science·2026
Same journal

Dual-Hit Myopia Mechanism Unveiled by Multi-Omics: Opn1mw Deficiency Primed the Retina for Exaggerated Response to Environmental Defocus.

Investigative ophthalmology & visual science·2026
Same journal

Psychometric Performance of Children With Amblyopia During a Tablet-Based Adaptive Visual Acuity Assessment.

Investigative ophthalmology & visual science·2026
See all related articles

The complement system is crucial for fighting Staphylococcus endophthalmitis. Decomplemented guinea pigs showed impaired defense against S. epidermidis and S. aureus infections.

Area of Science:

  • Ophthalmology
  • Immunology
  • Microbiology

Background:

  • The complement system plays a vital role in innate immunity.
  • Bacterial endophthalmitis is a serious ocular infection.
  • Staphylococcus epidermidis and Staphylococcus aureus are common causes of endophthalmitis.

Purpose of the Study:

  • To investigate the role of the complement system in host defense against Staphylococcus epidermidis and Staphylococcus aureus endophthalmitis.
  • To determine the impact of complement depletion on bacterial clearance in the eye.

Main Methods:

  • Guinea pigs were infected intravitreally with S. epidermidis or S. aureus.
  • Experimental groups were decomplemented using cobra venom factor.
  • Control groups received saline injections.

Related Experiment Videos

  • Bacterial counts in the vitreous and serum complement titers were measured.

    • Main Results:

    • Decomplemented animals had significantly higher bacterial loads in the vitreous for both S. epidermidis and S. aureus infections.
    • Serum complement titers were significantly reduced in decomplemented animals.
    • Host defense was impaired in the absence of functional complement.

    Conclusions:

    • The complement system is essential for effective host defense against S. epidermidis and S. aureus endophthalmitis.
    • Complement depletion leads to increased susceptibility to these infections.
    • Restoration of complement levels correlates with improved bacterial clearance.