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Gingival fluid IL-1 beta and IL-6 levels in menopause
R A Reinhardt1, M P Masada, J B Payne
1Department of Surgical Specialties, University of Nebraska Medical Center, Lincoln.
Journal of Clinical Periodontology
|January 1, 1994
Summary
Women experiencing menopause or oophorectomy without estrogen therapy (ED) show higher levels of interleukin-1 beta in gingival crevicular fluid (GCF). This suggests low estrogen environments increase bone-active cytokine production, impacting periodontal health.
Area of Science:
- Periodontology
- Endocrinology
- Immunology
Background:
- Menopause and oophorectomy without estrogen therapy (ED) are linked to increased bone-active cytokines from peripheral blood mononuclear cells.
- Estrogen deficiency may influence local inflammatory cytokine production.
Purpose of the Study:
- To compare gingival crevicular fluid (GCF) levels of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) in estrogen-deficient (ED) versus estrogen-sufficient (ES) postmenopausal women with periodontitis.
Main Methods:
- GCF samples were collected from 13 ED and 13 ES Caucasian adults with moderate-to-severe periodontitis.
- IL-1 beta and IL-6 levels were quantified using enzyme-linked immunosorbent assays (ELISAs).
Main Results:
- GCF IL-1 beta was detected significantly more frequently in ED subjects (92%) compared to ES subjects (23%).
- IL-6 was detected more frequently in ED subjects (23%) than ES subjects (8%), though not statistically significant due to short sampling times.
Conclusions:
- Clinical conditions associated with low estrogen environments promote increased local production of the bone-active cytokine IL-1 beta.
- These findings suggest a potential link between estrogen status, IL-1 beta elevation, and periodontal disease progression.