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[Intractable respiratory infections]

K Nakata1, T Nakatani, Y Nakamori

  • 1Department of Respiratory Medicine, Toranomon Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|February 1, 1994
PubMed
Summary

Silent aspiration frequently leads to bacterial infections in elderly patients. Diffuse panbronchiolitis patients with severe disease are prone to Pseudomonas aeruginosa superinfection, impacting prognosis.

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Area of Science:

  • Microbiology
  • Pulmonology
  • Infectious Diseases

Context:

  • Silent aspiration is a significant risk factor for bacterial infections in the elderly.
  • Bacterial infections, particularly superinfections, complicate the course of diffuse panbronchiolitis (DPB).
  • Pseudomonas aeruginosa superinfection is more common in DPB patients with prolonged disease, severe lung dysfunction, and advanced radiological findings.

Purpose:

  • To identify common bacterial pathogens associated with infections in elderly patients.
  • To investigate the factors predisposing to Pseudomonas aeruginosa superinfection in diffuse panbronchiolitis.
  • To evaluate the efficacy of long-term erythromycin administration in managing DPB exacerbations.

Summary:

  • Sixty-seven bacterial strains were isolated from infected elderly patients, with anaerobes, Streptococcus pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa being frequent isolates.
  • Gram-negative rods constituted 39% and anaerobes 19% of the isolated strains.
  • Long-term erythromycin therapy demonstrated potential in controlling acute exacerbations and reducing hospital admissions in DPB patients.

Impact:

  • Understanding common pathogens aids in targeted antimicrobial therapy for elderly patients.
  • Identifying risk factors for P. aeruginosa superinfection can guide preventive strategies in DPB.
  • Erythromycin may offer a therapeutic benefit in managing DPB, improving patient outcomes and reducing healthcare utilization.

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