Antigenic independence of some microbial urate oxidases

Antisera were prepared to urate oxidase derived from three microbial species, a yeast (Candida utilis), a mold (Aspergillus flavus), and a bacterium (Bacillus fastidious). The antisera inhibited enyme activity to a limited extent. Cross-reaction studies with preparations of the enzyme from these and other species indicated that the microbial enzyme exhibits a high degree of antigenic independence. This appeared to be particularly true of the bacteria studied.