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Related Experiment Videos

Myocardial lactate release during prolonged exercise under hypoxaemia

L Kaijser1, J Grubbström, B Berglund

  • 1Karolinska Institute, Department of Clinical Physiology, Huddinge Hospital, Stockholm, Sweden.

Acta Physiologica Scandinavica
|December 1, 1993
PubMed
Summary

During high-altitude exercise, the heart compensates for low oxygen by increasing blood flow. However, the heart also produces lactate, indicating a small shift to anaerobic metabolism for energy.

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Area of Science:

  • Cardiovascular Physiology
  • Altitude Physiology
  • Exercise Metabolism

Background:

  • Hypoxemia at high altitudes can impact cardiac function.
  • Understanding myocardial metabolism during exercise under reduced oxygen is crucial.

Purpose of the Study:

  • To investigate myocardial lactate production during exercise simulating 4500m altitude.
  • To determine if the heart shifts to anaerobic metabolism under hypoxemic conditions.

Main Methods:

  • Twelve healthy men underwent coronary sinus catheterization during exercise.
  • Breathing conditions alternated between normoxia and hypoxemia (12% O2).
  • Coronary blood flow, heart rate, and myocardial lactate exchange were measured.

Main Results:

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  • Myocardial oxygen uptake was similar in both conditions.
  • Increased coronary blood flow compensated for reduced arterial oxygen content.
  • Myocardial lactate release occurred during hypoxemic exercise, but not normoxemic exercise.

Conclusions:

  • Increased coronary blood flow almost fully compensates for reduced oxygen saturation during exercise.
  • A small portion (approx. 1%) of cardiac energy demand is met by anaerobic metabolism during hypoxemic exercise.