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Flavonoid-induced acute nephropathy

J L Lin1, Y S Ho

  • 1Division of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|March 1, 1994
PubMed
Summary
This summary is machine-generated.

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Flavonoids can cause acute kidney injury with hemolysis. Physicians should consider this cause of acute renal failure, especially with symptoms like cola-colored urine and jaundice, as flavonoids are widely used.

Area of Science:

  • Nephrology
  • Toxicology
  • Biochemistry

Background:

  • Flavonoids are widely consumed compounds with diverse biological activities.
  • Acute kidney injury (AKI) is a significant clinical concern with various etiologies.
  • The nephrotoxic potential of certain flavonoids requires further investigation.

Observation:

  • Two cases of acute renal failure (ARF) were linked to sciadopitysin, a flavonoid.
  • A literature review identified a total of eight patients with flavonoid-induced AKI.
  • Patients presented with fever, gastrointestinal upset, cola-colored urine, and jaundice.

Findings:

  • Flavonoid-induced AKI was characterized by hemolysis (100%), cholestatic hepatitis (50%), and disseminated intravascular coagulopathy (50%).
  • Laboratory findings included elevated blood urea nitrogen and serum creatinine lasting 2-9 weeks.

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  • Renal biopsies revealed acute interstitial nephritis and acute tubular necrosis, with novel polymorphous inclusion bodies observed via electron microscopy.

    • Implications:

    • Physicians should consider flavonoid ingestion as a potential cause of AKI, particularly in patients with hemolysis and jaundice.
    • Early recognition and management, including hemodialysis, are crucial for recovery.
    • Further research is needed to elucidate the precise pathogenetic mechanisms of flavonoid-induced nephropathy.