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Behavioral and neurochemical changes produced in rats by developmental treatments with psychotropic drugs
R Cagiano1, M A De Salvia, A Giustino
1Istituto di Farmacologia, Facoltà di Medicina e Chirurgia, Università degli Studi, Bari, Italy.
Annali Dell'Istituto Superiore Di Sanita
|January 1, 1993
Abstract:
The timing of developmental administration of psychotropic drugs affecting dopaminergic and GABAergic neurotransmission is crucial for the induction of specific neurobehavioral and neurochemical changes in rodents. Compensatory mechanisms occurring in response to a prolonged treatment with some neuroleptic and anxiolytic agents during development seem to be markedly different from those occurring in response to a prolonged administration in adult animals.