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Ketamine HCl, a dissociative anesthetic for squirrel monkeys (Saimiri sciureus)
Laboratory Animal Science
|December 1, 1975
Summary
Ketamine hydrochloride provided effective chemical restraint in squirrel monkeys at low doses. Higher doses induced anesthesia, with predictable recovery times and minimal mortality at extreme levels.
Area of Science:
- Veterinary Medicine
- Pharmacology
- Primate Research
Background:
- Chemical restraint is crucial for safe animal handling in research.
- Evaluating anesthetic agents in non-human primates requires careful dose-response studies.
Purpose of the Study:
- To determine the efficacy and safety of ketamine hydrochloride for chemical restraint and anesthesia in squirrel monkeys.
- To establish dose-response relationships for ketamine hydrochloride in this species.
Main Methods:
- Three experiments were conducted using squirrel monkeys.
- Ketamine hydrochloride was administered at varying doses to assess restraint and anesthetic effects.
- Serial dosing was employed to evaluate repeated administration impacts.
Main Results:
- Ketamine hydrochloride was effective for chemical restraint at doses below 13 mg/kg.
- Doses of 25 mg/kg and higher induced surgical anesthesia.
- Serial administration resulted in predictable anesthesia and recovery durations.
- Mortality was observed only at a high dose of 350 mg/kg.
Conclusions:
- Ketamine hydrochloride is a suitable agent for chemical restraint and anesthesia in squirrel monkeys.
- Dose selection is critical for achieving desired levels of sedation or anesthesia.
- The drug demonstrates a favorable safety profile with predictable outcomes in this species.