Ketamine HCl, a dissociative anesthetic for squirrel monkeys (Saimiri sciureus)

A series of 3 experiments performed in squirrel monkeys showed that ketamine HCl was satisfactory for chemical restraint at doses of less than 13 mg/kg. Doses of 25 mg/kg and above produced surgical anesthesia. When serial doses of ketamine HCl were given to squirrel monkeys at regular intervals, predictable anesthesia and recovery times were produced. Deaths occurred only at 350 mg/kg.