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Carbonic anhydrase activators. VII. Isozyme II activation by bisazolyl-methanes, -ethanes and related azoles
C T Supuran1, A T Balaban, P Cabildo
1University of Bucharest, Department of Chemistry, Roumania.
Biological & Pharmaceutical Bulletin
|December 1, 1993
Abstract:
A correlation was found between the carbonic anhydrase II activating power and the pKa values for a series of azoles, bisazolylmethanes and bisazolylethanes. Strong activations were found for compounds with pKa's in the interval 6.5-8.0. The mechanism of action for such activators is discussed.