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Core temperature rhythms in normal and tumor-bearing mice
D J Griffith1, J C Busot, W E Lee
1Department of Chemical Engineering, McNeese State University, Lake Charles.
Chronobiologia
|July 1, 1993
Summary
This study monitored core body temperature in mice with and without tumors. Tumor-bearing mice showed disrupted temperature rhythms, primarily affecting their active periods.
Area of Science:
- Physiology
- Oncology
- Animal Models
Background:
- Core body temperature exhibits a 24-hour rhythm in healthy individuals.
- Cancer can disrupt normal physiological rhythms, but the dynamics are not fully understood.
- Previous studies often used time-averaged data, limiting insights into dynamic changes.
Purpose of the Study:
- To quantify the temporal dynamics of core body temperature rhythm disruption in tumor-bearing mice.
- To investigate how ascites tumors affect circadian temperature regulation.
- To explore potential mechanisms beyond metabolic demands influencing temperature regulation.
Main Methods:
- Utilized surgically implanted radio telemetry transmitters for continuous core temperature monitoring.
- Compared temperature rhythms between normal DBA/2 mice and those with ascites tumors.
- Analyzed continuous temperature data over periods up to one month.
Main Results:
- Normal mice maintained a stable 24-hour temperature rhythm.
- Tumor-bearing mice exhibited a progressive deterioration of their temperature rhythm post-inoculation.
- Temperature regulation was specifically impaired during the active period in tumor-bearers.
- Findings suggest tumor influence on temperature regulation may involve non-metabolic pathways.
Conclusions:
- Ascites tumors significantly disrupt the circadian core body temperature rhythm in mice.
- The disruption primarily impacts the active phase of the circadian cycle.
- Malignancy appears to influence thermoregulation through mechanisms independent of the tumor's energy requirements.