Accumulation profiles during quasi-uniform multiple dosing regimens

An extension of the plasma area method of Chiou to the evaluation of accumulation profiles during quasi-uniform multiple dosing regimens (i.e., regimens with varying doses and/or dosing intervals within a certain time period which are repeated in the successive periods throughout the administration course) is presented. The derivations show, that the equations for the accumulation and steady state curves during quasi-uniform multiple dosing are similar or identical to these for the uniform multiple dosing case, if the constant time interval in the latter is replaced by the constant time period in the former. The equations derived can be used for rapid estimation of the time, required to reach a prespecified fraction of quasi steady state plasma level during quasi-uniform multiple dosing.