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Rice-based oral rehydration solution: a controlled trial in Nepal
1Eastern Region Hospital Ghopa, Dharan, Nepal.
Insights
Rice-based oral rehydration solution (ORS) proved more effective than glucose ORS in treating acute watery diarrhea in children under five. Rice ORS reduced stool frequency, offering a superior alternative for managing childhood diarrhea.
Area of Science:
- Pediatrics
- Gastroenterology
- Public Health
Background:
- Acute watery diarrhea is a leading cause of dehydration in children globally.
- Standard glucose-based oral rehydration solution (ORS) is the primary treatment.
- Exploring alternative ORS formulations can improve efficacy and patient outcomes.
Purpose of the Study:
- To compare the efficacy of rice-based ORS versus standard glucose ORS.
- To evaluate the impact on stool output and rehydration in children with acute watery diarrhea.
- To determine if rice ORS is a better alternative for managing diarrheal diseases.
Main Methods:
- A randomized controlled trial involving 148 children under 5 years old.
- Participants suffered from acute watery diarrhea with moderate to severe dehydration.
- Comparison of rice-based (50 g/l) ORS and standard glucose ORS intake and stool frequency.
Main Results:
- Children receiving rice ORS had significantly lower mean ORS intake (141.6 ml/kg/24h) compared to glucose ORS (205.2 ml/kg/24h).
- The mean number of diarrheal stools in the first 24 hours was significantly lower in the rice ORS group (5.4/24h) versus the glucose ORS group (6.8/24h).
- Both differences were statistically significant (P < 0.001).
Conclusions:
- Rice-based ORS demonstrates superior efficacy compared to standard glucose ORS in managing acute watery diarrhea in children.
- Rice ORS may lead to reduced stool frequency and potentially better rehydration.
- This suggests rice ORS is a beneficial alternative for pediatric diarrheal disease management.
Abstract:
The efficacy of rice-based (50 g/l) oral rehydration solution (ORS) was compared with standard glucose ORS in a randomized controlled trial in 148 children under 5 years of age, suffering from acute watery diarrhoea leading to moderate and severe dehydration. The mean ORS intake in the two groups of children were 141.6 and 205.2 ml/kg/24 hours, for rice ORS and glucose ORS, respectively (P < 0.001). The mean number of diarrhoeal stools in the first 24 hours in children of the rice ORS group was less when compared with the glucose ORS group (5.4 and 6.8/24 hours, respectively; P < 0.001). This study suggests that rice ORS is a better alternative to standard glucose ORS in the management of diarrhoeal diseases in children.