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Use of quantitative CT to predict postoperative lung function in patients with lung cancer
M T Wu1, J M Chang, A A Chiang
1Department of Radiology, Kaohsiung Veterans General Hospital, Taiwan, Republic of China.
Purpose:
To evaluate the effectiveness of quantitative computed tomography (CT) for predicting postoperative lung function in patients with lung cancer.
Materials And Methods:
Preoperative spirometry and conventional CT of the chest were performed in 38 patients. A postprocessing CT program was applied to quantitate the volume of whole-lung parenchyma with attenuations of -500 to -910 HU; this was defined as total functional lung volume (TFLV). The regional functional lung volume (RFLV) of the lobes or lung to be resected was quantitated separately. CT-predicted postoperative forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were derived by multiplying the preoperative spirometry values by (1 - RFLV/TFLV).
Results:
CT-predicted values correlated well with postoperatively measured results (FEV1: r = .93, P < .001; FVC: r = .86, P < .001) in patients who underwent pneumonectomy or lobectomy, regardless of the patient's preoperative ventilation status.
Conclusion:
This method is effective in the prediction of postoperative FEV1 and FVC in patients undergoing pulmonary resection.