p53 protein expression in squamocellular carcinomas of the lip
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Updated: Nov 9, 2026
07:50
Establishment of a Clinic-based Biorepository
Published on: May 29, 2017
Anticancer Research
|November 1, 1993
Abstract:
Twenty-six cases of squamocellular carcinomas of the lip were immunostained for p53 protein. Nuclear accumulation of p53 protein was observed in 88% of the 26 carcinomas, in 64% of adjacent "normal" epithelium and in all four cases with adjacent atypical squamous epithelium. 93% of the specimens (13/14) with p53 protein accumulation in "normal" epithelium demonstrated evidence of solar elastosis. UV radiation may induce p53 gene mutation as an early event in the neoplastic transformation.
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