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Scleromyxedema

R C Wright, R S Franco, D Denton

    Archives of Dermatology
    |January 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    A rare nodulocystic scleromyxedema case in a patient with psoriasis showed improvement with melphalan and prednisone therapy. Skin lesions resolved, but psoriasis symptoms later returned, indicating a complex interplay between these conditions.

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    Area of Science:

    • Dermatology
    • Internal Medicine

    Background:

    • Scleromyxedema, a rare mucinosis, presents a diagnostic challenge.
    • Co-occurrence of scleromyxedema and psoriasis is infrequently reported.

    Observation:

    • A 48-year-old male with a six-year history of psoriasis developed an unusual nodulocystic scleromyxedema.
    • The patient presented with significant perioral skin involvement affecting mobility.

    Findings:

    • Intermittent melphalan and prednisone therapy led to remission of scleromyxedema skin lesions.
    • Dermabrasion improved skin texture and perioral mobility.
    • Psoriasis recurred two months post-scleromyxedema remission.

    Implications:

    • This case highlights the potential for scleromyxedema to manifest in patients with pre-existing psoriasis.
  • The response to chemotherapy suggests a possible systemic inflammatory component.
  • Recurrence of psoriasis post-treatment warrants further investigation into disease interrelationships.