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Effect of systemic hyperandrogenism on the adrenal response to adrenocorticotropin hormone
E Katz1, W J Scherzer, R J Mansfield
1Division of Reproductive Endocrinology, University of Maryland, Baltimore.
Fertility and Sterility
|March 1, 1994
Abstract:
A virilized patient with an androgen-producing ovarian tumor was used to illustrate the effect of chronic hyperandrogenism on the adrenal response to ACTH. The accumulation rates of substrates for 3 beta-ol dehydrogenase, 21-hydroxylase, and 11 beta-hydroxylase remained unchanged after oophorectomy. This suggests that chronic hyperandrogenism does not affect the activity of enzymes involved in adrenal steroidogenesis.