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[Multiple antibiotic resistance in Haemophilus influenzae related to serogroup B]
J Campos1, T Seuba, G Trujillo
1Servicio de Microbiología, Hospital Sant Joan de Déu, Barcelona.
Aim:
To study the association between multiply antibiotic resistance in Haemophilus influenzae and H. influenzae type B, and to describe levels and patterns of antibiotic resistance.
Methods:
Statistical analysis and susceptibility of 231 H. influenzae strains (52 type B and 179 non-typable ) isolated consecutively from pediatric patients.
Results:
Resistance levels for type B and non-typable strains were: Ampicillin, 55.3% vs 28.8%; Chloramphenicol, 44.7% vs 9.2%; Ampicillin plus chloramphenicol, 40.4% vs 7.6%; cotrimoxazole, 89.3% vs 67.4%; resistance to six or more antibiotics, 36.0% vs 3.8%.
Conclusion:
Multiply antibiotic resistance in H. influenzae is strongly associated with type B strains, with age of 4 or younger, and with isolation from CSF or blood. Resistance is sustained over long periods of time.